Fast Track Preclinical Tools

 

Ab Initio has a specialist molecular, microbiology and in vitro testing facility. Using advanced cell culture models, we are able to evaluate NCEs and finished products. This allows our clients to predict numerous product properties such as inflammation, transport, metabolism and efficacy.

Learn how Ab Initio’s in vitro models can help you fast-track drug discovery and product development

Toxicity

EPITHELIAL CELL STUDIES

Using specific respiratory and nasal cell types, we are able to provide comprehensive API, excipient & formulation pre-clinical toxicity and cell response studies. This is essential at the early stages of product R&D to identify downstream clinical issues. 

Transport

REAL SYSTEMS

We have a number of bespoke models for evaluating aerosol deposition, transport and pharmacokinetics. We utilise both cell and non-cell based models, incorporated into conventional pharmacopeia apparatuses, to assess the deposition, transport and dissolution.

Effect

PHARMACOLOGY

We have a number of cell culture models for studying the interaction of your API or formulation at a cellular and molecular level. These include, mucus & cilia function models, inflammatory response, metabolic processes, cell migration and bacteriological assays.Phasellus sodales massa malesuada tellus fringilla, nec bibendum tellus blandit. Vestibulum ante ipsum primis in faucibus orci luctus et ultrices posuere cubilia Curae.

Applied Molecular Biology

  • Numerous cell models for evaluation formulation components including API and excipients

  • in vitro cell based 3D cell cultures for evaluation of finished products prototypes

  • Aerosol deposition apparatus for evaluation of inhaled particles

  • Lung epithelia and nasal epithelia models

    • Toxicity

    • Drug transport studies

    • Metabolises

  • Molecular biology models for the study of inflammation,

  • Microbiological models (including biofilms) for the study of infection